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Treatment-resistant Depression

Scott Aaronson, M.D.

What are the most promising therapies being researched that may work in the future for treatment-resistant depression?
There are many medications that are being researched, including those approved for other psychiatric conditions. For example, some antipsychotics (for schizophrenia) are being tested with antidepressants. There are studies on newer classes of medicines that affect different systems and different neurotransmitters in the brain.

Another type of treatment being studied is vagal nerve stimulation. This is a small device that is implanted and attached to the vagus nerve. It gives an impulse every 30 seconds.

What can family members do to help someone with treatment-resistant depression?
It is very important to be supportive, but make sure that you have someone to process your feelings with so you don't end up feeling depressed yourself.

If someone in your family is not getting better after several months, you may want to seek consultations from an expert in the field, in a particular specialty. It is helpful to see what courses of treatment another specialist may come up with.

If there is a local medical school in your area, you can call for referral recommendations or you can ask your own psychiatrist. If you're not located in a big city, you can contact an academic institution.

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© 2001 Families for Depression Awareness

Treatment-Resistant Depression
Dr. Scott Aaronson is the director of clinical research programs at the Sheppard Pratt Health System.

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